MRI Liver Obviates the Need for Liver Biopsy in Liver Donors
نویسندگان
چکیده
Background and Aim: Liver biopsy is the gold standard for determining acceptability of donors when CTLAI between -5 to +5. However, it invasive involves sampling only a small portion liver. CT does not reliably detect fibrosis, iron overload could lead erroneous selection donors. We propose that MRI- PDFF with elastography overcome these deficiencies. also wanted determine cut off value fat on MRI which would correspond 10% biopsy. Methods: 102 prospective liver underwent CTLAI, (PDFF, elastography, R2 sequencing) The strength association MRI-PDFF, content was determined by non-parametric correlation. Cut offs, sensitivity specificity MRI-PDFF steatosis or greater biopsies Receiver Operator Characteristic (RoC) curves. impacts offs across tests were determined. Results: Both correlated but had stronger correlation (Correlation coefficient 0.695 - MRI, -0.621 -CTLAI). Every unit increase in associated 0.5 fraction MRI. accepted cut-off 6.25% more sensitive than +5 >10% (AUROC 0.859 0.814 CTLAI). Conclusion: reliable non-invasive method donor assessment supersedes can obviate need A 6.25 % correlates macrosteatosis
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در نمونه برداری سوزنی کبد یا آسپیراسیون کبد، توسط سوزن نمونه برداری می توان نمونه ای از بافت کبدی را جهت تشخیص اکثر اختلالات کبدی، اثبات وجود سرطان کبد، یا ارزیابی اثرات داروهای آسیب رساننده به کبد تهیه کرد. همچنین با انجام نمونه برداری های مکرر روند پیشرفت و پاسخ بیماران به درمان بیماری های کبدی مزمنی چون هپاتیت فعال را می توان مشخص نمود.
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ژورنال
عنوان ژورنال: Journal of clinical and experimental hepatology
سال: 2023
ISSN: ['0973-6883', '2213-3453']
DOI: https://doi.org/10.1016/j.jceh.2023.07.123